Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients. (2025)

• Lewis JPDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland, 670 W. Baltimore St., Baltimore, MD 21201, USA.
• Backman JDDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland, 670 W. Baltimore St., Baltimore, MD 21201, USA.
• Reny JLDepartment of Internal Medicine, Béziers Hospital, 2 Rue Valentin Hau, BP 740, Béziers 34525, France.
• Bergmeijer TODepartment of Cardiology, Antonius Center for Platelet Function Research, St Antonius Hospital, P O Box 2500, Nieuwegein 3432 EM, The Netherlands.
• Mitchell BDDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland, 670 W. Baltimore St., Baltimore, MD 21201, USA.
• Ritchie MDCenter for Translational Bioinformatics, Institute for Biomedical Informatics, University of Pennsylvania, A301 Richards Building, 3700 Hamilton Walk, Philadelphia, PA 19104, USA.
• Déry JPQuebec Heart and Lung Institute, University Laval, 2725 chemin Sainte-Foy, Quebec City G1V 4G5, Canada.
• Pakyz REDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland, 670 W. Baltimore St., Baltimore, MD 21201, USA.
• Gong LDepartment of Biomedical Data Science, Stanford University, 443 Via Ortega, Room 213, Stanford, CA 94305, USA.
• Ryan KDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland, 670 W. Baltimore St., Baltimore, MD 21201, USA.
• Kim EYDepartment of Clinical Pharmacology, Inje University, Busan Paik Hospital, Bokji-ro 75, Busangjin-gu, Busan 614-735, South Korea.
• Aradi DDepartment of Cardiology, Heart Center Balatonfüred, 2 Gyogy Ter, Balatonfured 8230, Hungary.
• Fernandez-Cadenas IStroke Pharmacogenomics and Genetic Group, Fundació Docencia i Recerca Mutuaterrassa, 508221 Terrassa, Barcelona 8041, Spain.
• Lee MTMGenomic Medicine Institute, Geisinger Health System, 100 N. Academy Ave., Danville, PA 17822, USA.
• Whaley RMDepartment of Biomedical Data Science, Stanford University, 443 Via Ortega, Room 213, Stanford, CA 94305, USA.
• Montaner JNeurovascular Research Laboratory, Vall d'Hebron Institute of Research, Passeig Vall d'Hebron 119-129, Barcelona 8035, Spain.
• Gensini GFDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, Florence 50055, Italy.
• Cleator JHDivision of Cardiology, Vanderbilt University Medical Center, 2215B Garland Avenue, Nashville, TN 37232, USA.
• Chang KDepartment of Internal Medicine, Cardiology Division, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-Gu, Seoul 6591, South Korea.
• Holmvang LDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Inge Lehmannsvej 7 - 2142, Copenhagen 2100, Denmark.
• Hochholzer WDepartment of Cardiology and Angiology II, University Heart Center Freiburg, Suedring 15, Bad Krozingen 79189, Germany.
• Roden DMDepartment of Pharmacology, Vanderbilt University Medical Center, 2215B Garland Avenue, Nashville, TN 37232, USA.
• Winter SDr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, Stuttgart, 70376 Germany.
• Altman RBDepartment of Bioengineering, Genetics, and Medicine, Stanford University, 443 Via Ortega Drive, Shriram Room 209, Stanford, CA 94305, USA.
• Alexopoulos DDepartment of Cardiology, Patras University Hospital, Rio, Patras 26500, Greece.
• Kim HSDepartment of Clinical Pharmacology, Inje University, Busan Paik Hospital, Gaegum2-dong 622-165, Busanjin-Gu, Busan 614-735, South Korea.
• Gawaz MDepartment of Cardiology and Angiology, University of Tübingen, Otfired-Müller-Straße 10, Tübingen 72076, Germany.
• Bliden KPCenter for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, 3300 Gallows Rd, Falls Church, VA 22042, USA.
• Valgimigli MDepartment of Cardiology, Bern University Hospital, Freiburgstrasse 8, Bern 3010, Switzerland.
• Marcucci RDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, Florence 50055, Italy.
• Campo GDepartment of Cardiology, University Hospital of Ferrara, Via Aldo Moro 8, Cona (FE), Ferrara 44123, Italy.
• Schaeffeler EDr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, Stuttgart, 70376 Germany.
• Dridi NPDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Inge Lehmannsvej 7 - 2142, Copenhagen 2100, Denmark.
• Wen MSDivision of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou and School of Medicine, Chang Gung University, No. 5, Fuxing St, Guishan Dist., Taoyuan City 333, Taiwan.
• Shin JGDepartment of Clinical Pharmacology, Inje University, Busan Paik Hospital, Gaegum2-dong 622-165, Busanjin-Gu, Busan 614-735, South Korea.
• Fontana P Department of Medicine, Geneva Platelet Group, University of Geneva School of Medicine, University Hospitals of Geneva, 24 rue du Général-Dufour, Genève 4 CH-1211, Switzerland.
• Giusti BDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, Florence 50055, Italy.
• Geisler TDepartment of Cardiology and Angiology, University of Tübingen, Otfired-Müller-Straße 10, Tübingen 72076, Germany.
• Kubo MLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, 1-7-22, Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan.
• Trenk DDepartment of Cardiology and Angiology II, Clinical Pharmacology, University Heart Centre Freiburg, Suedring 15, Bad Krozingen D-79189, Germany.
• Siller-Matula JMDepartment of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria.
• Ten Berg JMDepartment of Cardiology, Antonius Center for Platelet Function Research, St Antonius Hospital, P O Box 2500, Nieuwegein 3432 EM, The Netherlands.
• Gurbel PADepartment of Cardiology and Angiology, University of Tübingen, Otfired-Müller-Straße 10, Tübingen 72076, Germany.
• Schwab MDr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, Stuttgart, 70376 Germany.
• Klein TEDepartment of Biomedical Data Science, Stanford University, 443 Via Ortega, Room 213, Stanford, CA 94305, USA.
• Shuldiner ARDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland, 670 W. Baltimore St., Baltimore, MD 21201, USA.

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Published in:

Clopidogrel

Pharmacogenetics

Platelet aggregation

Aged

Brain Ischemia

Clopidogrel

Coronary Artery Disease

Coronary Thrombosis

Decision Support Techniques

Europe

Female

Humans

Male

Middle Aged

Myocardial Infarction

Percutaneous Coronary Intervention

Pharmacogenomic Variants

Platelet Aggregation

Platelet Aggregation Inhibitors

Polymorphism, Single Nucleotide

Predictive Value of Tests

Risk Assessment

Risk Factors

Stents

Stroke

Treatment Outcome